K Ognatan1,
K Adi1,3,
C Lamboni1 
,
J M Damorou2,
K A Aklikokou3,
M Gbeassor3,
J C Guilland4
For correspondence:- C Lamboni Email: rlamboni@tg.refer.org Tel:002289032990
Received: 9 September 2010 Accepted: 25 August 2011 Published: 23 October 2011
Citation: Ognatan K, Adi K, Lamboni C, Damorou JM, Aklikokou KA, Gbeassor M, et al. Effect of Dietary Intake of Fermented Seeds of Parkia biglobosa (Jacq) Benth (African Locust Bean) on Hypertension in Bogou and Goumou-kope Areas of Togo. Trop J Pharm Res 2011; 10(5):603-609 doi: 10.4314/tjpr.v10i5.9
© 2011 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To identify the possible effect of the consumption of fermented seeds of Parkia biglobosa (Jack) Benth, Mimosaceae (African locust bean) by humans on the prevention of hypertension.
Methods: Two types of populations in Togo were identified and compared: one type was in a region (Bogou) where the condiment (Parkia biglobosa seeds) is highly consumed and the other people do not eat it at all (Goumou-kope). Anthropometrical, clinical and biochemical analyses were investigated in both target groups.
Results: Significantly decreased blood pressure and heart beat were detected in the group of people living in Bogou’s region when compared to the non-consumption group of Goumou-kope (p < 0.001). Magnesium level was significantly increased in the Bogou group compared to that in the second group (p < 0.0001). Lower levels of low density lipoprotein-cholesterol (91± 36 vs. 110 ± 44 mg/dL, p = 0.01), triglycerides (111 ± 6 vs. 129 ± 6 mg/dL, p = 0.028), and higher levels of high density lipoprotein-cholesterol (63 ± 2 vs. 48 ± 3 mg/dL, p < 0.001) were observed in subjects who regularly consummed P. biglobosa fermented seeds. Furthermore, plasma glucose concentration was significantly lower in Bogou group than in Goumou-kope (68 ± 16 vs. 76 ± 15 mg/dL (p < 0.001).
Conclusion: The results of the present study demonstrate that fermented seeds of Parkia biglobosa exert an anti-hypertension effect.
Archives
News Updates
Fulltext in PDF